Nexlizet long-term side effects remain an issue for many patients that need lifelong cholesterol control. The bempedoic acid/ezetimibe combination Nexlizet is designed to reduce LDL cholesterol levels, but long-term efficacy may be called into question.
Muscle-related symptoms like myalgia were described in 6% of patients based on long term data, with this article focusing almost exclusively to these recent findings. This may be a bigger problem with long-term use, particularly in people prone to statin-induced muscle pain. Muscle at risk for weakness is more obviously affected in these populations, making it equally imperative that muscle health be monitored.
Another important side effect is the elevation of liver enzymes which can be observed in around 2% cases during long-term therapy. Persistent elevation of liver enzymes would suggest impending damage to the liver and may need ongoing monitoring with by frequent LFTs. It is absolutely imperative for those with pre-existing liver disease, who will likely face a greater degree of risk as time moves forward.
Hyperuricemia, seen in around 4% of Nexlizet users, was another long-range risk. Untreated, chronic gout can become a painful condition that might require long-term medical management for you. This should be less of a concern insofar as the patient has not been previously diagnosed to have gout, but patients with a history of gout will need to keep that risk in mind and discuss safety precautions (including dietary measures such avoiding alcohol or purine-rich foods), etc., with their healthcare professional.
Gastrointestinal symptoms, such as abdominal pain and diarrhea, are possible in about 5% of patients yet not fully resolved after long term therapy. While most of these side effects are mild, they can be highly pernicious inhibiting desirable patient medication compliance. Long-term abdominal pain can also cause other problems, as nutrient malabsorption or weight loss (1).
Long-term risk is a very rare but serious complication for active patients and includes tendon rupture. Seen in fewer than 1% of patients, this side effect could have long-term effects on mobility and physical function. Patients using physical activities, should be informed and instructed to reduce this risk.
Allergic reactions can also emerge or get worse as time goes on, although the risk of such is quite low. These reactions are seen in less than 1% of patients, although this number should be taken with a grain of salt as long-term use could heighten sensitivity. If rash, itching or facial swelling should occur this requires immediate medical treatment.
Patients being treated with Nexlizet long-term should continue to discuss these and other potential risks of treatment. It is important to monitor liver function, uric acid and muscle health as well regular overall clinical evaluation. For further information on nexlizet side effects, please see here for a selection of medical sources accurate to your query and consult always with healthcare professional.